Skip to main content

Peptide Drug Discovery And Advance

Many biotechnologists and preclinical pharmacology specialists may not agree, but peptide drugs provide demonstrable commercial success. Over 50 peptide related medications that had annual sales of over $1 billion each were sold back in 2010. The most valuable property of these drugs is their ability to fight cancer, prevent its spread, and eradicate metabolic diseases. Currently, researchers are trying to determine if peptides can serves as vaccines, antimicrobials, or contraceptives. Stakeholders in the health sector are optimistic that peptide drug discovery and current efforts to stabilize the medication will make health care services readily available.

There are host of sources of peptides; they are readily available in multicellular and unicellular organisms. Additionally, they can be acquired from chemical libraries and recombinant. They provide a greater chemical diversity than other classes of biological molecules. Due to their easy degradation, peptides are administered through injections. Since they occur naturally, peptides are safer than artificial medication. They have a higher selectivity, efficacy, and specificity. Their bioactivities are important for drug discovery and include amino acids and coordination of major physiological processes. Therefore, they can neutralize complications at a faster rate than synthetic medications.

When peptides degrade completely, they turn into proteinogenic amino acids without necessarily releasing harmful metabolites. Synthetic drugs produce toxic metabolites that may cause other complications and they might have serious side effects. The popularity of peptides has been increasing on a fast rate over the past few years. Their short half-life ensures that metabolites circulate in the blood for a short duration.

In contrast to antibodies and bigger proteins, peptides have ability to penetrate deep into the tissue at a fast rate. Additionally, their manufacturing cost is significantly lower than recombinant antibodies and proteins. Due to their high stability and activity, these drugs can be put in storage at a room temperature. Most of them are acquired from polypeptides or protein and they can intermingle with membrane proteins. Activation or deactivation of some target receptors is possible when small amount of peptides are utilized. Currently, very few peptides antagonists that promote ligand-receptor reactions are available on the market.

The health care market has experienced a significant increase in the number of peptides that are launched each year. Most of them are peptide hormones and derivatives that promote hormone action. The increase in popularity of these drugs began back in 2010. However, some of medications that were launched in 2010 have been withdrawn.

Currently, scientists are conducting a series of clinical trials to determine the efficacy of peptides. Those under trials are believed to have properties of healing several infectious disease and oncology. They are introduced into the body through intravenous and subcutaneous techniques.

The major challenge that is hindering commercialization of peptides is its administration procedure and easy degradation. Researchers are trying to come with solutions that allow administration of peptides in a form that is not easily degraded in the digestive system. The collaboration of stakeholders in the health industry and scientist is likely to bear fruits.

Stabilization of peptides through optimization is a strategy that scientists are currently using. The first clinical trial involved administering the drug, which was encapsulated with silica particles into the alimentary canal of animals. The outer coat lowers the rate of degradation and promotes circulation of the drug in the body longer.

Comments

Popular posts from this blog

Top 5 Costume Ideas For Nigerians Attending A Halloween Party

Halloween, an annual holiday celebrated on the 31st of October in several countries around the world, including Australia, Canada and the United States of America, is not a Nigerian culture and has never been announced as an official holiday in the country. However, thanks to Nigeria’s love for anything “western world” and their proclivity for revelry, some people in the country are now seen dressed up in elaborate costumes and trick or treating around major cities on Halloween day every October.

This year, from Club Illusion’s Halloween party set to hold on Friday 28th October at Concord Owerri to Halloween Party – THE LIGHTHOUSE, holding Saturday 29th October 2016 at Marina Lagos, there are so many events already lined up for Halloween. And with the D-day fast approaching, we at Nigeria World News know that it’s crunch time for finding the perfect costume. Given that we know your costume is preying on your mind, we have come up with unique ideas for costumes that can reflect the Ni…

How To Choose A Fishing Rod And How To Make It Last

No sportsman wins by sheer talent alone. No matter how talented a sportsman is, if his equipment is not good enough, his chances of winning will remain slim. That is because his equipment will hinder rather than help his game. A runner needs good shoes to run. A bowler needs a bowling ball that weighs and fits right in his hand. The same goes with a fisherman and his fishing rod.

Fishing is a sport that many people find enjoyable. It is always a challenge to get the elusive fish to bite the bait, and sitting still for hours on the end just to be able to catch fish can be very relaxing. But regardless of the challenge and the relaxation that fishing offers, the goal of fishing is still to catch some fish. Barring bad luck and circumstances that are really unfavorable for fishing, a good fishing rod is necessary for a good catch.

If you are a beginner at fishing, it is perfectly all right to use a simple fishing rod and reel – nothing spiffy and nothing fancy. When you are jus…

5 Reasons Men Cheat On Their Partners

Are you a woman who suspects that your man is cheating on you? If you do, you may be interested in catching them in the act. But, first, you may have a number of questions. One of the most common questions asked by women who have been cheated on is “why do men cheat?”


When it comes to determining why men cheat on their wives or their girlfriends, it is difficult to come up with an exact reason. Why? Because men cheat for a wide range of different reasons. For example, your boyfriend may cheat for one reason, but one another man may be cheating for a whole other reason.

Despite the fact that it is difficult to determine exactly why men cheat, namely your man, there are a number of common reasons. These reasons, a few of which are highlighted below, may be the cause of your cheating husband or boyfriend.
To Get Out of a Relationship

What do you do when you decide that you went to end a relationship? If you are like many other women, you breakup with your boyfriend or ask for a d…